Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models
نویسندگان
چکیده
Faculty of Technology and Metallurgy, Belgrade, Serbia National Cancer Research Center of Serbia Faculty of Chemistry, University of Belgrad Innovation Center of the Faculty of Chemis 12-16, Belgrade, Serbia Institute of Chemistry, Technology and Met 12, Belgrade, Serbia Institut Pluridisciplinaire Hubert Curien, UM 67401 Illkirch, France. E-mail: cdmuller@u Faculty of Agriculture, University of Belgrad [email protected] † Electronic supplementary informa 10.1039/c6ra23940d Cite this: RSC Adv., 2016, 6, 104763
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A new series of N-(5-Mercapto-1,3,4-thiadiazol-2-yl)-2-phenylacetamide derivatives (3a-3j) were synthesized via an amidation reaction using EDC and HOBt in acetonitrile solvent at room temperature condition. Chemical structures were characterized by 1H NMR, IR and MS spectroscopic methods and related melting points were also determined. The anticancer activity was evaluated using MTT procedure ...
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